Food waste represents one of the most pressing global challenges, with approximately one-third of all food produced for human consumption lost or wasted annually. Post-harvest losses account for a significant portion of this waste, particularly in developing countries where inadequate infrastructure and poor handling practices contribute to substantial economic and environmental impacts. This comprehensive review examines current post-harvest management techniques designed to minimize food waste, including advanced storage technologies, preservation methods, cold chain management, and innovative packaging solutions. The analysis reveals that implementing proper post-harvest management strategies can reduce food losses by 15-50% while extending shelf life and maintaining nutritional quality. This paper synthesizes recent research findings and technological innovations to provide evidence-based recommendations for sustainable post-harvest management practices.